论文部分内容阅读
聚合物用作药物控制释放载体时,具有释药浓度可控、药物的生物利用度高、可实现靶向治疗等优点。但有些聚合物存在机械强度低、化学稳定性差和生物相容性不理想等缺点。二氧化硅(SiO2)具有多孔、无毒、生物相容性好、化学和机械稳定性高、表面易功能化等优点,但SiO2用作药物控制释放载体时,也存在载药量低、不能装载大分子药物、不能实现靶向释放等缺点。聚合物/SiO2杂化材料作为药物控制释放载体,可有效结合二者的优点,并克服二者的缺陷。根据聚合物的种类和杂化体系性质的不同,本文分别对温敏性聚合物/SiO2杂化材料、聚电解质/SiO2杂化材料、生物高分子/SiO2杂化材料以及其他一些聚合物/SiO2杂化材料体系在药物控制释放中的应用进行了介绍,并展望了该领域今后的研究发展方向。
When the polymer is used as a drug carrier for controlled release, it has the advantages of controlled release concentration, high bioavailability of drugs, and targeted therapy. However, some polymers have the disadvantages of low mechanical strength, poor chemical stability and unsatisfactory biocompatibility. Silica (SiO2) is porous, nontoxic, has good biocompatibility, high chemical and mechanical stability and easy surface functionalization. However, when SiO2 is used as a controlled release carrier, Loaded macromolecular drugs, can not achieve the targeted release and other shortcomings. Polymer / SiO2 hybrid materials as a controlled release drug carrier, which can effectively combine the advantages of both and overcome the shortcomings of both. Depending on the type of polymer and the nature of the hybrid system, the effects of temperature-sensitive polymer / SiO2 hybrid material, polyelectrolyte / SiO2 hybrid material, biopolymer / SiO2 hybrid material and other polymers / SiO2 The application of hybrid material system in drug controlled release is introduced, and the future research direction in this field is prospected.