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司莫司汀属亚硝脲类烷化剂,为洛莫司汀的衍生物,抗肿瘤机制与卡氮芥相似。因可透过血脑屏障,临床上除了适用于恶性黑色素瘤、恶性淋巴瘤外,对脑瘤及各种恶性肿瘤脑转移也有疗效[1]。本药口服吸收迅速,易为患者接受,临床应用日渐广泛。其对骨髓、消化道及肝肾有毒性。我们报道1?
Semustine is a nitrosourea alkylating agent, a derivative of lomustine, has an antitumor mechanism similar to that of carmustine. Because of the blood-brain barrier can be passed, in addition to clinically applicable to malignant melanoma, malignant lymphoma, brain metastases of brain tumors and various malignancies are also effective [1]. The rapid absorption of oral drugs, easy for patients to accept, increasingly widespread clinical application. Its bone marrow, digestive tract and liver and kidney toxicity. We report 1?