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我们曾观察到骨碎补具有降低血清脂质及防止动脉粥样硬化斑块形成的作用。现从骨碎补中分离提取出一种白色结晶,溶于丙酮等有机溶媒,经植化试验和红外、紫外光谱及核磁共振波谱分析以及扫描电镜拍摄观察,认为是骨碎补双氢黄酮甙(简称DF),我们对其进行了初步药理学研究。对家兔原位心实验:家兔8只,用Cushny法,用药前心脏收缩曲线高度为3.69±0.296cm (?),iv 0.5%DF溶液10～12.5mg/kg,5分钟后,曲线即开始升高,40分时可高达9.54±1.18cm(P<0.001)。对小鼠常压耐缺氧的影响:给药组(11只),ip,0.5%DF溶液1.25mg/10g,存活时间为16.05±1.15分。对照组(10只)ip,等容积生理盐水,存活
We have observed that Rhizoma Drynaria has the effect of lowering serum lipids and preventing the formation of atherosclerotic plaques. Now from the broken broken up in the extract isolated a white crystal, soluble in acetone and other organic solvents, the plantation test and infrared, ultraviolet and nuclear magnetic resonance spectroscopy and scanning electron microscopy observation, that is the bone dry flavanoid glycosides (Referred to as DF), we carried out preliminary pharmacological studies. In situ rabbit heart test: 8 rabbits, Cushny method, before treatment systolic curve height 3.69 ± 0.296cm (?), Iv 0.5% DF solution 10 ~ 12.5mg / kg, 5 minutes after the curve Began to rise, 40 minutes up to 9.54 ± 1.18cm (P <0.001). The effects of hypoxia on the pressure of the mice at normal pressure: the administration group (11), ip, 0.5mg DF solution 1.25mg / 10g, the survival time was 16.05 ± 1.15 minutes. Control group (10) ip, equal volume of saline, survive