论文部分内容阅读
目的比较厄贝沙坦、硝苯地平及美托洛尔治疗原发性高血压逆转左心室肥厚的作用。方法选择150例原发性高血压伴左心室肥厚患者,随机分为厄贝沙坦组(A组)、硝苯地平控释片(B组)及美托洛尔组(C组)各50例。全组患者未曾接受降压治疗(或仅用过利尿剂)或已停用降压药物3周以上。A组服用厄贝沙坦150~300 mg,1次/d,B组服用硝苯地平控释片30~60 mg,1次/d,C组服用美托洛尔25~50 mg,2次/d;疗程均为24周。观察治疗前后血压及超声心动图变化。结果各组患者治疗后血压均显著降低(P<0.01),组间降压幅度无明显统计学差异(P>0.05)。各组患者治疗后舒张期左室后壁厚度、舒张期室间隔厚度、左室舒张末期内径及左室重量指数均有显著改善(P<0.05,0.01)。而且A组左室重量指数下降优于B、C组(P<0.05)。结论三种药物在有效降压的同时均可逆转左心室肥厚,厄贝沙坦对左心室肥厚的逆转作用相对更强。
Objective To compare the effects of irbesartan, nifedipine and metoprolol on treating left ventricular hypertrophy in patients with essential hypertension. Methods A total of 150 patients with essential hypertension and left ventricular hypertrophy were randomly divided into two groups: irbesartan (group A), nifedipine controlled release (group B) and metoprolol (group C) example. All patients had not received antihypertensive therapy (or diuretics only) or had been deprived of antihypertensive drugs for more than 3 weeks. Group A received irbesartan 150-300 mg once daily, group B received nifedipine 30-60 mg once daily, group C received metoprolol 25-50 mg twice daily, / d; treatment were 24 weeks. Changes of blood pressure and echocardiography before and after treatment were observed. Results After treatment, the blood pressure was significantly decreased in all groups (P <0.01). There was no significant difference in the amplitude of blood pressure between the two groups (P> 0.05). The diastolic left ventricular posterior wall thickness, diastolic interventricular septum thickness, left ventricular end-diastolic diameter, and left ventricular mass index in each group were significantly improved after treatment (P <0.05,0.01). Moreover, the decrease of left ventricular mass index in group A was better than that in group B and C (P <0.05). Conclusions All three drugs can reverse left ventricular hypertrophy at the same time of effective antihypertensive treatment. Irbesartan is more effective in reversing left ventricular hypertrophy.