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近十年来,由于新型防腐剂在化妆品、洗涤剂以及油漆、粘胶等工业用品中的广泛使用,使过敏性接触性皮炎明显增多。作者用小鼠局部淋巴结检测法(LLNA)比较了这些防腐剂中含有的3种主要杀虫剂——5-氯-2-甲基-4-异噻唑啉-3-酮(CMIT),2-甲基-4,5-三甲烯基-4-异噻唑啉-3-酮(MTI)和1,2-苯异噻唑啉-3-酮(BIT)的致敏能力。选用6～8周CBA/Ca小鼠,药品溶解在二甲基甲酰胺(DMF)中,每浓度的药品用4只小鼠,在每只小鼠耳背部涂25μl,对照组涂用DMF,连续涂3天,初次用药5
The past decade, due to the new preservatives in cosmetics, detergents and paints, adhesives and other industrial products in the widespread use of allergic contact dermatitis significantly increased. The authors compared three major insecticides, 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) -methyl-4,5-tnetryl-4-isothiazolin-3-one (MTI) and 1,2-benzisothiazolin-3-one (BIT). Selection of 6 to 8 weeks CBA / Ca mice, the drug was dissolved in dimethylformamide (DMF), the concentration of drugs with 4 mice, each mouse ear coated with 25μl, the control group coated with DMF, Apply three consecutive days, the first medication 5