Stability of proteins with multi-state unfolding behavior

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过去常计算蛋白质展开的免费精力变化的一个新模型被介绍。在这个模型,蛋白质被认为由结构的元素构成。展开一个结构的元素服从二状态的机制和元素的免费精力变化能被一个线性推测方法获得。如果蛋白质由一样的结构的元素组成,它的展开的愿望显示一个二状态的过程,和仅仅平均结构的元素免费精力变化 G element0 (H2O ) 能被测量。如果蛋白质由完全不同的结构的元素组成,它展开将显示出多状态行为。当蛋白质由 n 组成时它的展开的愿望显示出的结构的元素一(n+1 ) 说行为。最少平方的试穿能被用来分析每个结构的元素的
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