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好多年来,就已经认识到垂体促性腺激素的分泌受着环境刺激和性腺类固醇的影响。在某些动物种属中,性交可引起排卵、以及光线可改变动情周期就是环境影响的例证。性腺类固醇对促性腺激素分泌的影响是很复杂的,有人报告,随着情况不同,雌激素和黄体酮,可抑制也可刺激促性腺激素的分泌。这方面的进展,曾由于缺乏灵敏的方法而受到阻碍,近来由于 Parlow 发现了一种高度灵敏的黄体化激素(L.H.)的检定方法,卵巢抗坏血酸降低法,大大地便利了我们对控制这种促激素分泌因素的了解。在这篇讨论中,作者拟就本课题的近代知识加以综述。在评论所用的方法之后,就概述影响促黄体化激素分泌的因素,接着讨论此促激素的神经调节,最后,将对促黄体化激素的调节和其他促性腺激素,卵泡刺激素(FSH)和黄体刺激素(LTH)的调节之间加以比较。
For many years, it has been recognized that the secretion of pituitary gonadotropin is influenced by environmental stimuli and gonadal steroids. In some animal species, intercourse can cause ovulation, and light can change the cycle of estrus is an example of environmental impact. Gonadal steroids on the secretion of gonadotropin is very complex, it was reported, with different conditions, estrogen and progesterone, can inhibit but also stimulate gonadotropin secretion. Progress in this area has been hampered by the lack of responsiveness, and recently, as Parlow discovered a highly sensitive assay for luteinizing hormone (LH), the ovarian ascorbate reduction method greatly facilitated our efforts to control this Understanding of hormone secretion factors. In this discussion, the author intends to summarize the modern knowledge of this topic. After reviewing the methodology used, the factors that affect the secretion of luteinizing hormone are summarized, followed by discussion of the neuromodulation of this hormone, and finally, the regulation of luteinizing hormone and other gonadotropins, follicle stimulating hormone (FSH) and Luteinizing hormone (LTH) regulation between the comparison.