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目的观察肾炎康复片联合标准激素治疗老年气阴两虚证肾病综合征的疗效及不良反应。方法选择2013年10月—2014年9月期间收治的肾病综合征患者120例,随机分入观察组(60例)和对照组(60例)。所有患者给予口服泼尼松,初始计量每天1 mg/kg,观察组在此基础上联用肾炎康复片,8片/次,3次/d。治疗12个月后,比较患者治疗前后的24 h尿蛋白、血清白蛋白、总胆固醇、甘油三酯、血小板、血浆垂体腺苷酸环化酶激活肽的变化,比较2组患者治疗后的临床疗效。结果治疗后,观察组患者总有效(95.0%)显著高于对照组(78.3%),观察组患者的血小板数为(161.64±20.63)×10~9/L,改善效果显著优于对照组的(171.24±21.86)×10~9/L,观察组患者24 h尿蛋白定量为(1.75±0.52)g,改善效果显著优于对照组的(3.03±1.72)g,观察组患者的血清白蛋白、总胆固醇、甘油三酯以及血浆垂体腺苷酸环化酶激活肽改善效果显著优于对照组,差异具有统计学意义(P<0.05)。观察组的不良反应发生率(33.3%)明显低于对照组(68.3%),差异具有统计学意义(P<0.05)。结论肾炎康复片与标准激素联合治疗老年气阴两虚证肾病综合征,能够有效缓解患者的临床症状,改善其相关指标,提高其临床疗效,同时降低不良反应发生率,且预后较好。
Objective To observe the efficacy and adverse reactions of nephritis and kang yang tablets combined with standard hormone in the treatment of nephrotic syndrome of old-qi and yin-deficiency syndrome. Methods One hundred and twenty patients with nephrotic syndrome who were admitted between October 2013 and September 2014 were randomly divided into observation group (60 cases) and control group (60 cases). All patients were given oral prednisone, the initial daily dose of 1 mg / kg, the observation group on this basis with nephritis rehabilitation tablets, 8 tablets / time, 3 times / d. Twelve months after treatment, 24 h urinary protein, serum albumin, total cholesterol, triglyceride, platelet and plasma pituitary adenylate cyclase activating peptide in 24 h patients were compared before and after treatment. Efficacy. Results After treatment, the total effective rate (95.0%) in the observation group was significantly higher than that in the control group (78.3%). The number of platelets in the observation group was (161.64 ± 20.63) × 10 ~ 9 / L, (171.24 ± 21.86) × 10 ~ 9 / L, the urinary protein in 24 hours of observation group was (1.75 ± 0.52) g, and the improvement effect was significantly better than that of the control group (3.03 ± 1.72) g. Serum albumin , Total cholesterol, triglycerides and plasma pituitary adenylate cyclase activating peptide improved significantly better than the control group, the difference was statistically significant (P <0.05). The incidence of adverse reactions in the observation group (33.3%) was significantly lower than that in the control group (68.3%), the difference was statistically significant (P <0.05). Conclusion Shenyinkang tablets combined with standard hormones in the treatment of nephrotic syndrome of the old Qi-Yin deficiency syndrome can effectively relieve the clinical symptoms, improve the related indexes, improve the clinical curative effect, reduce the incidence of adverse reactions and have a good prognosis.