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目的检测慢性肾功能衰竭患者血浆同型半胱氨酸水平,探索其与健康人的差异及临床意义。方法运用荧光偏振免疫分析法测定35例慢性肾功能衰竭患者(包括非透析和透析患者)和30例健康者的血浆同型半胱氨酸水平。结果慢性肾功能衰竭组血浆同型半胱氨酸水平为(44±32)μmol/L,显著高于正常对照组(10.4±2.7)μmol/L,P<0.01。结论检测慢性肾功能衰竭患者血浆同型半胱氨酸水平,对慢性肾功能衰竭的治疗具有重要的指导意义。
Objective To detect plasma homocysteine levels in patients with chronic renal failure and to explore the differences and clinical significance between them and healthy individuals. Methods Plasma homocysteine levels were measured in 35 patients with chronic renal failure (including non-dialysis and dialysis patients) and 30 healthy controls by fluorescence polarization immunoassay. Results The level of plasma homocysteine in chronic renal failure group was (44 ± 32) μmol / L, which was significantly higher than that of the normal control group (10.4 ± 2.7) μmol / L, P <0.01. Conclusion Detection of plasma homocysteine levels in patients with chronic renal failure has important guiding significance for the treatment of chronic renal failure.