论文部分内容阅读
目的 探讨细胞因子TNF α、IL 1、IL 6与癌症恶病质的关系 ,观察消炎痛对癌症恶病质的治疗效果。方法 用肺腺癌 (LA795 )接种T739小鼠建立癌症恶病质实验模型 ,测定荷瘤前后不同阶段小鼠血清IL 6、IL 1、TNF α的水平及血糖、甘油三酯和总蛋白的变化及体重变化 ,并且观察消炎痛对癌症恶病质的治疗效果。结果 癌症恶病质小鼠的体重、血糖、血甘油三酯、血总蛋白显著低于非荷瘤组 ,而血清IL 6、TNF α和IL 1水平显著高于非荷瘤组。消炎痛治疗后 ,恶病质小鼠的体重、摄食量、血糖、血甘油三酯和血总蛋白水平较生理盐水对照组显著提高且生存时间延长 ,同时 ,IL 6、TNF α、IL 1的血清水平显著低于生理盐水对照组。结论 IL 6、TNF α、IL 1参与了本动物模型的癌症恶病质诱导。通过抑制IL 6、TNF α、IL 1的升高 ,消炎痛具有改善癌症恶病质的作用。
Objective To investigate the relationship between cytokines TNF α, IL 1, IL 6 and cancer cachexia, and to observe the therapeutic effects of indomethacin on cancer cachexia. Methods The experimental model of cancer cachexia was established by inoculating lung adenocarcinoma (LA795) into T739 mice. The levels of serum IL 6, IL 1, and TNF α and the changes of blood glucose, triglyceride, total protein and weight were measured before and after tumor implantation. Change and observe the therapeutic effect of indomethacin on cancer cachexia. Results The mice with cancer cachexia had significantly lower body weight, blood glucose, serum triglyceride and total blood protein than non-tumor-bearing mice. Serum levels of IL 6, TNF α and IL 1 were significantly higher than those of non-tumor-bearing mice. After treatment with indomethacin, the body weight, food intake, blood glucose, serum triglyceride and total blood protein levels of cachexia mice were significantly higher than those in the normal saline control group, and the survival time was prolonged. At the same time, serum levels of IL 6, TNF α, and IL 1 were elevated. Significantly lower than the saline control group. Conclusion IL 6, TNF α, and IL 1 are involved in cancer cachexia induction in this animal model. By inhibiting the increase of IL 6, TNF α, and IL 1, indomethacin has the effect of improving cancer cachexia.