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目的了解Ⅲ期直肠癌术后患者同步放化疗疗效及不良反应。方法 74例Ⅲ期直肠癌术后患者,随机分成观察组和对照组,各37例,对照组予以单纯性化疗,实验组施以同步放化疗治疗,观察两组临床疗效及不良反应发生情况。结果实验组总有效率(75.68%)明显优于对照组(62.16%),但并发症发生率(59.46%)显著高于对照组(27.03%),组间比较差异具有统计学意义(P<0.05)。结论Ⅲ期直肠癌术后患者同步放化疗疗效优于单纯性化疗,但不良反应相对较高,临床上应引起足够重视。
Objective To understand the efficacy and adverse reactions of concurrent chemoradiotherapy in patients with stage Ⅲ rectal cancer after operation. Methods Totally 74 patients with stage Ⅲ rectal cancer were randomly divided into observation group and control group, 37 cases in each group. The control group received simple chemotherapy and the experimental group received concurrent chemoradiotherapy. The clinical efficacy and adverse reactions of the two groups were observed. Results The total effective rate (75.68%) in the experimental group was significantly better than that in the control group (62.16%), but the complication rate (59.46%) was significantly higher than that in the control group (27.03%), with significant difference between the two groups (P < 0.05). Conclusions The efficacy of concurrent chemoradiotherapy in patients with stage Ⅲ rectal cancer is superior to that of simple chemotherapy, but the adverse reactions are relatively high and should be paid enough attention in clinic.