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目的 :研究卡维地洛治疗急性心肌梗死 (AMI)及其抗氧自由基 (OFR)的作用。方法 :4 4例AMI患者随机分成治疗组 (2 3例 ) ,对照组 (2 1例 ) ,两组在治疗相同的基础上 ,治疗组加服卡维地洛片 ,每次 10～ 2 0mg ,每日 2次。服药 4 8h后抽血查血清丙二醛 (MDA)含量 ,做心电图、2 4h动态心电图。并在 2周病情稳定后进行超声心动图检查 ,观察两组患者的心率、心律失常发生率及左室射血分数 (LVEF)。结果 :治疗组MDA含量低于对照组 (P <0 .0 5 ) ,心率、心律失常发生率明显低于对照组 (P <0 .0 1) ;而LVEF高于对照组 (P <0 .0 5 )。结论 :卡维地洛具有抗氧化性质 ,能有效地清除AMI时OFR ,降低心律失常发生 ,促进心功能恢复 ,是治疗AMI的理想药物。
Objective: To study the effect of carvedilol on acute myocardial infarction (AMI) and its antioxidant free radical (OFR). Methods: Forty four patients with AMI were randomly divided into treatment group (23 cases) and control group (21 cases). On the basis of the same treatment, the patients in the treatment group were treated with carvedilol tablets (10-20 mg each time) , 2 times a day. Blood samples were taken after 48h serum malondialdehyde (MDA) content, do electrocardiogram, 24 h Holter. Echocardiography was performed after 2 weeks of stable disease. The heart rate, incidence of arrhythmia and left ventricular ejection fraction (LVEF) were observed in two groups. Results: The MDA content in the treatment group was lower than that in the control group (P <0.05). The incidence of heart rate and arrhythmia was significantly lower in the treatment group than in the control group (P <0.01). The LVEF was higher in the treatment group than in the control group (P <0. 0 5). CONCLUSION: Carvedilol is an ideal drug for the treatment of acute myocardial infarction (AMI) due to its anti-oxidative properties, effectively clearing OFR during AMI, reducing arrhythmia and improving cardiac function.