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本文采用流式细胞仪对51例慢性肝病患者外周血淋巴细胞亚群进行了测定。结果发现慢性活动性肝炎（CAH）、慢性迁延性肝炎（CPH）和肝炎后肝硬化（HC）患者与正常对照相比，NK数量明显增加（P＜0．01），CD4+和CD3+数量均明显降低（P＜0．01），CAH的CDS+数量明显增加（P＜0．01），且CD4+／CDS+比值明显下降（P＜0．01），HC的CD4+／CD8+比值也下降（P＜0．05）。NK与CD8+数量的变化规律为CAH＞HC＞CPH＞正常对照。CD4+、CD4+／CDS+变化规律为正常对照＞CPH＞HC＞CAH，提示淋巴细胞亚群的变化与肝细胞受损程度及疾病活动密切相关。
In this paper, 51 cases of chronic liver disease patients with peripheral blood lymphocyte subsets were determined by flow cytometry. The results showed that compared with the normal control, the number of NK increased significantly (P <0.01) and the number of CD4 + and CD3 + in chronic active hepatitis (CAH), chronic persistent hepatitis (CPH) and posthepatitic cirrhosis (HC) (P <0.01), and the ratio of CD4 + / CDS + decreased significantly (P <0.01) and the ratio of CD4 + / CD8 + of HC decreased (P <0.01) .05). The change rule of NK and CD8 + was CAH> HC> CPH> normal control. The changes of CD4 +, CD4 + / CDS + were normal control> CPH> HC> CAH, suggesting that the changes of lymphocyte subsets are closely related to the degree of liver cell damage and disease activity.