传统认为,阿片只通过作用于中枢神经系统(CNS)产生止痛效应。而从近来诸资料看,它还能作用于CNS以外的外周局部受体产生抗感受伤害作用。Wood是最早报道者之一,他把吗啡涂在外周疼痛区域时,发现可产生止痛效应。后来,大量类似的临床和实验报告相继出现。然而在早期多数学者认为这是一种偶然现 Traditionally, opioids only produce analgesic effects by acting on the central nervous system (CNS). From the recent data, it can also act on peripheral receptors outside the CNS produce anti-sense injury. Wood was one of the earliest reporters who found analgesic effects when he painted morphine in peripheral pain areas. Later, a large number of similar clinical and experimental reports appeared one after another. However, in the early days most scholars thought it was a coincidence