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目的 探讨中国汉族人群中胰高血糖素受体 (GCGR)基因Gly4 0Ser多态性与 2型糖尿病的相关性。方法 采用聚合酶链反应 寡核苷酸连接测定方法 ,对北京地区 10 2对病例 对照配偶对进行GCGR基因Gly4 0Ser多态性基因型检测。结果 病例组和对照组共 2 0 4例样本中均未发现GCGR基因Gly4 0Ser突变。 结论 在中国汉族人群中GCGR基因Gly4 0Ser多态性对 2型糖尿病的发生可能影响不大。
Objective To investigate the association between Glu40Ser polymorphism of glucagon receptor (GCGR) and type 2 diabetes mellitus in Chinese Han population. Methods Polymerase chain reaction oligonucleotide ligation assay was used to detect GCGR gene Gly4 0Ser polymorphism in 102 pairs of case-control mate pairs in Beijing. Results No GCGR gene Gly4 0Ser mutation was found in 204 cases in both cases and controls. Conclusion GCGR gene Gly4 0Ser polymorphism in Chinese Han population may have little effect on the occurrence of type 2 diabetes.