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目的:探析益肾颗粒剂与霉酚酸酯对狼疮性肾炎患者临床疗效及神经肽Y(NPY)水平的影响。方法:选取2010年3月至2015年5月该院收治的狼疮性肾炎患者48例,随机分为实验组和对照组各24例。对照组单纯给予霉酚酸酯治疗,实验组给予霉酚酸酯联合益肾颗粒剂治疗,观察两组患者临床疗效以及神经肽Y水平变化情况。结果:实验组患者治疗总有效率83.3%显著高于对照组患者治疗总有效率(66.7%,P<0.05),经治疗后实验组患者NPY水平改善情况明显优于对照组(P<0.05)。结论:采用霉酚酸酯联合益肾颗粒剂治疗狼疮性肾炎患者,临床疗效显著,并能有效降低患者神经肽Y水平。
Objective: To investigate the effects of Yishen Granule and mycophenolate mofetil on the clinical efficacy and neuropeptide Y (NPY) levels in patients with lupus nephritis. Methods: Forty-eight patients with lupus nephritis admitted to our hospital from March 2010 to May 2015 were randomly divided into experimental group (24 cases) and control group (24 cases). The control group was treated with mycophenolate mofetil alone. The experimental group was treated with mycophenolate moxibustion and Yishen Granule. The clinical efficacy and neuropeptide Y levels in both groups were observed. Results: The total effective rate of experimental group was 83.3%, which was significantly higher than that of control group (66.7%, P <0.05). After treatment, the improvement of NPY level in experimental group was significantly better than that of control group (P <0.05) . Conclusion: The combination of mycophenolate moxibustion and Yishen granule in the treatment of patients with lupus nephritis, the clinical efficacy was significant, and can effectively reduce the level of neuropeptide Y.