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目的··：观察四氢原小檗碱同类物（ＴＨＰＢｓ）对吗啡依赖小鼠和大鼠戒断症状的影响。方法··：以连续递增剂量方式ｓｃ盐酸吗啡，建立吗啡依赖小鼠和大鼠模型，ｉｐＴＨＰＢｓ２０ｍｉｎ后，用环丙羟丙吗啡（小鼠５ｍｇ·ｋｇ－１，大鼠２ｍｇ·ｋｇ－１，ｉｐ）催瘾。结果··：小鼠分别ｉｐｌ－四氢巴马汀（ｌ－ＴＨＰ，１５，３０，６０ｍｇ·ｋｇ－１）、ｌ－千金藤啶碱（ｌ－ＳＰＤ，１５，３０，６０ｍｇ·ｋｇ－１）和ｄｌ－四氢巴马汀（ｄｌ－ＴＨＰ，１５，３０，６０ｍｇ·ｋｇ－１）可显著抑制其跳台反应，降低跳台次数，减少体重下降。大鼠分别ｉｐｌ－ＴＨＰ（１０，２０，４０ｍｇ·ｋｇ－１）和ｄｌ－ＴＨＰ（１０，２０，４０ｍｇ·ｋｇ－１）能够抑制１ｈ体重下降，大大改善戒断时的行为表现，减轻腹泻和流涎，症状评分随剂量增加而下降。ｌ－ＳＰＤ抑制大鼠戒断症状作用虽无剂量依赖关系，但１０ｍｇ·ｋｇ－１却可减轻大鼠２４ｈ体重下降。结论··：ＴＨＰＢｓ可缓解吗啡依赖小鼠和大鼠戒断症状，可能具有临床应用价值。
Objective: To observe the effects of tetrahydroprotoberberine (THPBs) on withdrawal symptoms in morphine-dependent mice and rats. Methods · · ·: morphine-dependent mice and rat models were established by continuous escalation of dose-time morphine hydrochloride. After ipTHPBs for 20 min, the mice were challenged with cyclophosphamide (5 mg · kg -1, 2 mg · kg -1, ip ) Addiction. Results: The mice were treated with ipl-tetrahydropalmatine (l-THP, 15, 30, and 60 mg · kg -1) ) And dl-tetrahydropalmatine (dl-THP, 15, 30 and 60 mg · kg-1) could significantly inhibit the platform reaction, reduce the number of platform trips and reduce weight loss. Rat ipl-THP (10,20,40 mg · kg-1) and dl-THP (10,20,40 mg · kg-1) could inhibit 1h weight loss, greatly improve the performance of withdrawal, reduce diarrhea and Salivation, symptom scores decreased with dose. l-SPD inhibited withdrawal symptoms in rats without a dose-dependent manner, but 10mg · kg-1 can reduce the weight loss in rats 24h. Conclusions ··: THPBs can relieve morphine-dependent mice and rats with withdrawal symptoms may have clinical value.