论文部分内容阅读
目的:探讨血清前列腺特异性抗原(PSA)预测BPH发生急性尿潴留(AUR)的临床意义。方法:回顾性分析2005年1月~2013年9月收住我院确诊为BPH的患者临床资料,共386例,将其分为尿潴留组与非尿潴留组,应用统计学方法比较两组间之间血清总前列腺特异性抗原(tPSA)、前列腺体积(PV)、前列腺特异性抗原密度(PSAD)是否存在差异,寻找能够准确预测尿潴留的临床指标;应用Sperman’s相关分析,了解变量之间的关系;应用受试者工作特征曲线(ROC曲线),确定相关指标预测AUR的分界值。结果:尿潴留组中tPSA、PV、PSAD均明显高于非尿潴留组,上述指标在两组患者中存在显著差异;随着tPSA、PV、PSAD的增高,尿潴留的发生率逐渐增加;tPSA、tPSA/年龄、PSAD的ROC曲线下面积大致相同。结论:tPSA、tPSA/年龄、PV、PSAD可作为前列腺增生发生AUR的预测因素,从而对是否对疾病尽早进行有效干预及疾病的预后起着重要的作用。
Objective: To investigate the clinical significance of serum prostate specific antigen (PSA) in predicting acute urinary retention (AUR) in BPH. Methods: The clinical data of 386 patients admitted to our hospital from January 2005 to September 2013 were retrospectively analyzed. The data were divided into urinary retention group and non-urinary retention group, and statistical methods were used to compare the two groups (TPSA), prostate volume (PV) and prostate specific antigen density (PSAD) were determined to find the clinical indexes that could accurately predict urinary retention. Sperman’s correlation analysis was used to find out the relationship between the variables The receiver operating characteristic curve (ROC curve) was used to determine the cutoff value of the related index prediction AUR. Results: The levels of tPSA, PV and PSAD in urinary retention group were significantly higher than those in non-urinary retention group. There was significant difference between the two groups of patients; the incidence of urinary retention gradually increased with the increase of tPSA, PV and PSAD; tPSA , TPSA / age, PSAD ROC area under the roughly the same. Conclusion: tPSA, tPSA / age, PV, PSAD can be used as predictors of AUR in prostatic hyperplasia, which plays an important role in effective early intervention and prognosis of the disease.