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目的 通过对人肺癌组织Na+/H+交换蛋白 - 1(NHE - 1)mRNA表达的检测 ,探讨肿瘤治疗新的特异靶点。 方法 采用RNA原位分子杂交法 (RNA -IMH)检测了 16例人肺癌组织NHE - 1mRNA的表达。 结果 人肺癌组织NHE - 1mRNA的表达与正常肺组织相比显著增强 ,呈现过表达 ,而各病理类型间无显著差异。 结论 人肺癌组织NHE - 1mRNA的过表达 ,这一有别于正常肺组织细胞的分子生物学特征可能为肿瘤治疗学提供良好的特异靶点
Objective To investigate the expression of Na+/H+ exchanger protein-1 (NHE-1) mRNA in human lung cancer tissues and explore new specific targets for tumor treatment. Methods The expression of NHE-1 mRNA in 16 human lung cancer tissues was detected by RNA in situ hybridization (RNA-IMH). Results The expression of NHE-1 mRNA in human lung cancer tissues was significantly increased compared with normal lung tissues, and overexpression was observed. There was no significant difference among the pathological types. Conclusion The overexpression of NHE-1 mRNA in human lung cancer tissue, which is different from the normal lung tissue, may provide a special target for tumor therapeutics.