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目的探讨番茄红素对大鼠急性心肌缺血所致心肌损伤的保护作用。方法 60只雄性Wistar大鼠随机分为三组,分别为对照组、番茄红素高剂量组(10 mg/kg.bw)、番茄红素低剂量组(5 mg/kg.bw),对照组灌喂橄榄油,番茄红素组灌喂番茄红素。4周后,结扎大鼠心脏左冠状动脉前降支,建立大鼠急性心肌缺血模型,记录心电图,心脏切片计算心肌梗死面积。结果番茄红素可明显缩小梗死面积,番茄红素高剂量组几乎无心颤与心速,图形较好,6 h成活率100%,与对照组比较差异有统计学意义(P<0.05);低剂量图形次于高剂量,有少量的心速、早搏波,6 h成活率与对照组比较差异有统计学意义(P<0.05)。结论番茄红素对急性心肌缺血具有明显保护作用,对缺血诱发的心律失常亦有治疗作用,其机制可能与其增强抗氧化酶活性,减少自由基对心肌的氧化损伤,稳定生物膜有关。
Objective To investigate the protective effect of lycopene on myocardial injury induced by acute myocardial ischemia in rats. Methods Sixty male Wistar rats were randomly divided into three groups: control group, high lycopene group (10 mg / kg.bw), low lycopene group (5 mg / kg.bw), control group Irrigation olive oil, lycopene group fed lycopene. Four weeks later, the left anterior descending coronary artery of rats was ligated and the model of acute myocardial ischemia was established. The area of myocardial infarction was calculated by electrocardiogram and heart biopsy. Results Lycopene significantly reduced infarct size. The high-dose lycopene group had almost no heart-fibrillation and heart rate, and the pattern was good with a survival rate of 100% at 6 h, which was significantly different from that of the control group (P <0.05). Low The dose pattern was inferior to the high dose, with a small amount of heart rate, premature beat wave, 6 h survival rate compared with the control group, the difference was statistically significant (P <0.05). Conclusions Lycopene has a significant protective effect on acute myocardial ischemia and also has therapeutic effect on ischemia-induced arrhythmia. The mechanism may be related to enhancing antioxidant enzyme activity, reducing oxidative damage of myocardial and stabilizing biofilm.