氨氯地平是第三代二氢吡啶类钙拮抗剂(钙离子拮抗剂或慢通道阻滞剂)。心肌和平滑肌的收缩依赖于细胞外钙离子通过特异性离子通道进入细胞。本品选择性抑制钙离子跨膜进入平滑肌细胞和心肌细胞,对平滑肌的作用大于心肌。其与钙通道的相互作用决定于它和受体位点结合和解离的渐进性速率,因此药理作用逐渐产生。 Amlodipine is the third generation of dihydropyridine calcium antagonists (calcium antagonists or slow channel blockers). The contraction of myocardium and smooth muscle relies on extracellular calcium ions entering cells through specific ion channels. This product selectively inhibits calcium transmembrane into smooth muscle cells and myocardial cells, the role of the smooth muscle is greater than the myocardium. Its interaction with the calcium channel is determined by its gradual rate of binding to and dissociation from the acceptor site, so that pharmacological effects are gradually produced.