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目的探讨联合使用乳酸左氧氟沙星与细辛脑治疗肺气肿感染的临床疗效。方法选取广西天等县人民医院2014年9月—2016年1月期间收治的经确诊为肺气肿感染的患者94例,随机分为观察组和对照组,每组47例。观察组给予乳酸左氧氟沙星联合细辛脑治疗,对照组给予头孢呋辛钠治疗,7 d为1个疗程,两组均连续治疗2个疗程。观察两组临床治疗疗效,并记录患者各项体征指标改善时间及治疗期间不良反应发生情况。采用SPSS19.0统计软件进行统计分析,计量资料用均数±标准差(±s)表示,采用t检验,计数资料用率(%)表示,采用χ~2检验,P<0.05表示差异有统计学意义。结果观察组治疗总有效率为89.36%显著高于对照组72.34%(P<0.05)。观察组体温恢复时间(3.59±1.49)d、临床症状缓解时间(5.84±1.60)d、X线片表现消失时间(8.93±1.42)d及住院时间(10.40±2.21)d显著比对照组(5.47±1.18)、(9.95±2.74)、(10.26±1.33)、(12.64±1.90)d短,两组差异有统计学意义(P<0.01)。观察组不良反应发生率为10.64%与对照组8.51%比较,差异无统计学意义(P>0.05)。结论联合使用乳酸左氧氟沙星与细辛脑治疗肺气肿感染的临床疗效显著,患者临床症状改善明显,恢复快,不良反应轻微。
Objective To investigate the clinical efficacy of combination of levofloxacin lactate and asarone in the treatment of emphysema infection. Methods Ninety-four patients diagnosed as emphysema who were admitted to Tianhe County People’s Hospital of Guangxi from September 2014 to January 2016 were randomly divided into observation group and control group, with 47 cases in each group. Observation group was given levofloxacin lactate combined with asarone treatment, the control group was given cefuroxime sodium treatment, 7 d for a course of treatment, two groups were treated for 2 courses. The curative effect of the two groups was observed, and the time of improvement of each symptom index and the occurrence of adverse reactions during the treatment were recorded. Statistical analysis was performed with SPSS19.0 statistical software. The measurement data were expressed as mean ± standard deviation (± s), t test was used and the data rate (%) was used as the count data. Chi-square test was used to test the difference Statistical significance. Results The total effective rate of the observation group was 89.36%, which was significantly higher than that of the control group (72.34%, P <0.05). The recovery time of body temperature (3.59 ± 1.49) d, the clinical symptom relief time (5.84 ± 1.60) days, the disappearance time of X-ray film (8.93 ± 1.42) d and hospitalization time (10.40 ± 2.21) d in observation group were significantly higher than those in control group ± 1.18), (9.95 ± 2.74), (10.26 ± 1.33) and (12.64 ± 1.90) d respectively. There was significant difference between the two groups (P <0.01). The incidence of adverse reactions in the observation group was 10.64% compared with 8.51% in the control group, with no significant difference (P> 0.05). Conclusions The combination of levofloxacin lactate and asarone is effective in treating emphysematous infection. The clinical symptoms of the patients are obviously improved, the recovery is rapid and the adverse reaction is slight.