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[目的]观察乌司他丁注射液在腹部手术围术期中的应用及对机体炎症反应和肾功能的影响.[方法]腹部手术患者180例,随机分为对照组(n=90)和观察组(n=90).对照组围术期静滴葡萄糖注射液,观察组静滴乌司他丁注射液,比较两组患者机体炎症因子及肾功能指标的变化和术后并发症发生情况.[结果]两组术前干扰素β(IFN-β)、肿瘤坏死因子-α(T NF-α)及白细胞介素-6(IL-6)等炎症因子水平及肾功能指标血尿素氮、尿酸及肌酐水平相比较差异无显著性(P>0.05);观察组术后各炎症因子水平,血尿素氮、尿酸及肌酐水平均明显低于对照组,且差异有显著性(P<0.05).;观察组术后并发症发生率为4.44%(4/90),低于对照组的11.11%(10/90),且两组比较差异有显著性(P0.05);The levels of inflammatory fac-tors,blood urea nitrogen,uric acid and creatinine in the observation group were significantly lower than those in the con-trol group,and the difference was significant(P <0.05);The postoperative complication rate of the observation group was 4.44%(4/90),which was lower than that of the control group 11.11%(10/90),and the difference between the two groups was significant(P <0.05).[Conclusion]Ulinastatin injection is ideal for patients undergoing abdominal surgery.It can reduce the inflammatory response and improve the renal function of patients.