胃癌是人类最常见的恶性肿瘤之一,手术切除仍是最主要的治疗手段,绝大多数早期胃癌通过手术可以获得治愈,但手术不能改变残留癌细胞局部复发及远处转移的生物学特性,尤其是进展期胃癌术后局部复发和转移的发生率仍可高达60%以上。胃癌术后的辅助化疗在临床开展已有半个多世纪, Gastric cancer is one of the most common human malignant tumors. Surgical resection is still the most important treatment. Most of the early gastric cancer can be cured by surgery. However, the surgery can not change the biological characteristics of the local recurrence and distant metastasis of residual cancer cells. In particular, the incidence of postoperative local recurrence and metastasis of advanced gastric cancer can still be as high as 60%. Adjuvant chemotherapy for gastric cancer has been in clinical practice for more than half a century,