论文部分内容阅读
目的探讨微生态制剂联合头孢哌酮钠舒巴坦钠对肝硬化并发自发性腹膜炎患者血清中白细胞介素-12(IL-12)、IL-18及C-反应蛋白(CRP)水平的影响。方法选取郑州人民医院2014年5月—2016年7月收治的89例肝硬化并发自发性腹膜炎患者,随机分组,对照组44例,观察组45例,对照组予以单一头孢哌酮钠舒巴坦钠治疗,观察组给予头孢哌酮钠舒巴坦钠加双歧三联活菌片治疗,观察比较两组临床治疗效果及血清IL-12、IL-18、CRP水平,并统计比较两组治疗后并发症发生情况及治疗前后日常生活能力评分。结果观察组治疗总有效率为95.56%(43/45),高于对照组79.55%(35/44),差异具有统计学意义(P<0.05);治疗后观察组IL-12、IL-18及CRP水平均低于对照组,差异具有统计学意义(P<0.05);观察组并发症发生率为8.89%(4/45),对照组为4.55%(2/44),组间对比差异无统计学意义(P>0.05)。结论双歧三联活菌片联合头孢哌酮钠舒巴坦钠治疗可有效改善肝硬化并发自发性腹膜炎患者日常生活能力及炎症因子水平,提高疗效,且安全性高。
Objective To investigate the effect of probiotics combined with cefoperazone sodium and sulbactam sodium on the levels of interleukin-12 (IL-12), interleukin-18 and C-reactive protein (CRP) in patients with cirrhosis and spontaneous peritonitis. Methods 89 patients with cirrhosis complicated with spontaneous peritonitis admitted to Zhengzhou People’s Hospital from May 2014 to July 2016 were randomly divided into control group (n = 44) and observation group (n = 45). The control group received single cefoperazone sodium and sulbactam sodium, The observation group was treated with cefoperazone sodium and sulbactam sodium plus bifidobacterium triple viable tablets. The clinical therapeutic effect and the levels of serum IL-12, IL-18 and CRP in the two groups were observed and compared. The complication and treatment were compared between the two groups Before and after the daily living ability score. Results The total effective rate in the observation group was 95.56% (43/45), which was higher than that in the control group (79.55%, 35/44) (P <0.05). After treatment, the levels of IL-12 and IL- (P <0.05). The incidence of complications in the observation group was 8.89% (4/45), while that in the control group was 4.55% (2/44). There was significant difference between the two groups No statistical significance (P> 0.05). Conclusion Bifidobacterium triple viable tablets combined with cefoperazone sodium and sulbactam sodium can effectively improve the daily living ability and inflammatory cytokines in cirrhotic patients with spontaneous peritonitis and improve the curative effect with high safety.