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目的 :观察庆大霉素负荷量法治疗儿童感染性腹泻的疗效及对肾、耳的毒性。方法 :治疗组 2 40例采用庆大霉素 4mg (kg·d) ,qd ,负荷量给药方案 ,对照组 190例采用 4mg (kg·d) ,分 3次给药方案。结果 :治疗组、对照组总有效率分别为 90 .0 % ,71.0 % ,差异极显著 ( P <0 .0 1) ,治疗组、对照组肾、耳毒性发生率分别为 1.3 % ,4.4% ,差异显著 ( P <0 .0 5 )。结论 :庆大霉素负荷量治疗方案优于每日 3次给药方案 ,且肾、耳毒性较小。
Objective: To observe the curative effect of gentamycin loading on children with infectious diarrhea and its toxicity to kidney and ear. Methods: Two hundred and forty cases in the treatment group were treated with 4 mg (kg · d) of gentamicin and the dosage of qd was used. In the control group, 190 cases were treated with 4 mg (kg · d) for three times. Results: The total effective rates of treatment group and control group were 90.0% and 71.0%, respectively, the difference was significant (P <0.01). The incidence of kidney and ototoxicity in treatment group and control group were 1.3% and 4.4% , Significant difference (P <0. 05). Conclusion: The gentamycin load treatment scheme is better than the 3 times daily dosage regimen, and the renal and ototoxicity is small.