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目的研究人白细胞抗原HLA-B蛋白在喉癌组织中的表达及意义。方法应用免疫组化方法检测HLA-B蛋白在50例喉癌组织及癌旁组织的表达,应用Western Blot方法检测HLA-B蛋白在6对喉癌及癌旁组织中的表达。结果 HLA-B蛋白在癌旁正常组织中100%表达,而在喉癌组织中表达水平明显下调,有淋巴结转移组下调明显低于无淋巴结转移组。结论 HLA-B蛋白在喉癌组织中表达下调,可能与颈淋巴结转移相关。
Objective To study the expression of human leukocyte antigen HLA-B in laryngeal squamous cell carcinoma and its significance. Methods Immunohistochemistry was used to detect the expression of HLA-B protein in 50 cases of laryngeal carcinoma and its adjacent tissues. Western Blot was used to detect the expression of HLA-B protein in 6 cases of laryngeal carcinoma and its adjacent tissues. Results The expression of HLA-B protein was 100% in the adjacent non-cancerous adjacent tissues, while it was down-regulated in the laryngeal carcinoma. The lymph node metastasis was significantly lower than that in the non-lymph node metastasis group. Conclusion The expression of HLA-B protein in laryngeal carcinoma is down-regulated, which may be related to cervical lymph node metastasis.