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[目的]研究热休克蛋白60(HSP60)和p53在胃癌组织中的表达,并分析与胃癌临床病理特征的关系。[方法]采用免疫组化SABC法检测48例胃癌组织和14例正常胃黏膜中HSP60和p53的蛋白表达。[结果]胃癌组织中HSP 60和p53蛋白表达阳性率分别为81.3%、68.9%;HSP60在胃癌中表达与肿瘤分化程度及增殖能力有关(P<0.05);p53蛋白在胃癌中表达与肿瘤大小、部位、浸润深度、淋巴结转移和肿瘤增殖能力有关(P<0.05);HSP60与p53的表达无相关性。而HSP60在正常胃黏膜中有弱阳性表达(7.1%),在正常胃黏膜中未见p53表达。[结论]HSP60和p53表达与胃癌生物学行为有关,在胃癌的发生、发展过程中发挥着重要的作用。
[Objective] To investigate the expression of heat shock protein 60 (HSP60) and p53 in gastric cancer and their relationship with the clinicopathological features of gastric cancer. [Method] The protein expressions of HSP60 and p53 in 48 cases of gastric carcinoma and 14 cases of normal gastric mucosa were detected by immunohistochemical SABC method. [Results] The positive rate of HSP 60 and p53 protein in gastric cancer was 81.3% and 68.9%, respectively. The expression of HSP60 in gastric cancer was correlated with the degree of tumor differentiation and proliferation (P <0.05). The expression of p53 protein in gastric cancer was correlated with tumor size , Location, depth of invasion, lymph node metastasis and tumor proliferation (P <0.05). There was no correlation between the expression of HSP60 and p53. However, HSP60 had a weak positive expression in normal gastric mucosa (7.1%) and no p53 expression in normal gastric mucosa. [Conclusion] The expression of HSP60 and p53 is related to the biological behavior of gastric cancer and plays an important role in the occurrence and development of gastric cancer.