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目的 观察沙培林对胸腔恶性肿瘤术后胸腔积液的疗效 ,了解其毒副作用并探讨其作用机制。方法 选择 1998～ 2 0 0 1年胸腔恶性肿瘤术后胸腔积液 2 8例 ,术后第二天开始平均胸引量大于 30 0ml的病例 ,自胸管内注入沙培林 5KE闭管 ,8小时后开放 ,观察 2 4小时并记录引流量 ,若引流量大于 10 0ml,再注入 3KE后拔管 ,治疗前后摄胸片对照 ,治疗前胸引量按每日胸引量及 3天胸水量之和评估 ,治疗后以胸片或B超定位胸穿抽液为准。结果 2 8例中完全缓解 2 1例 ( 75 %) ,部分缓解 6例 ( 2 1 4 %) ,总有效率 96 4 %。结论 沙培林胸腔内注射治疗胸腔恶性肿瘤术后胸腔积液疗效肯定 ,不良反应主要是发热 ,胸痛 ,无肝肾等不良反应。
Objective To observe the curative effect of sapirin on pleural effusion after thoracic malignant tumor and to understand its toxic and side effects and to explore its mechanism. Methods 28 cases of malignant pleural effusion after thoracic malignant tumor from 1998 to 2001 were selected. The average thoracic index was more than 30 0 ml on the second day after operation. After opening, observed 24 hours and recorded drainage, drainage if the volume is greater than 10 0ml, and then injected into the 3KE after extubation, before and after treatment of chest radiograph control before treatment, thoracic ejections according to the daily volume of thoracic and 3 days of hydrothorax And assessment, after treatment to chest X-ray or chest ultrasound fluid shall prevail. Results 21 cases (75%) were relieved in 2 of 8 cases, 6 cases (21.4%) were partially relieved, and the total effective rate was 96.4%. Conclusion Shaplein injection of pleural effusion after pleural effusion pleural effusion positive effect, adverse reactions are mainly fever, chest pain, no adverse reactions such as liver and kidney.