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给草原兔尾鼠(Laguruslagurus)经腹腔接种不同量的婴儿利什曼原虫(Leishmaniainfantum)前鞭毛体,结果表明,不同量的原虫感染对动物体重及肝重没有明显的影响,但脾重则有一定的差异。肝脏原虫负荷随感染虫量的增加而加大,实验结果进一步证明草原兔尾鼠是一种对利什曼原虫非常敏感的实验动物;同时在用级差较小的不同量的原虫接种后,可以显示感染程度的差别,这就为利什曼病的免疫学研究提供了良好的动物模型。
Different doses of Leishmania inanthevis were administered to Lagurus lagurus via intraperitoneal inoculation. The results showed that different doses of protozoa had no significant effect on body weight and liver weight, but spleen weight had Certain differences. The protozoal load of liver increased with the increase of infected worms. The experimental results further prove that the prairie rabbits are a kind of experimental animals very sensitive to Leishmania; at the same time, after inoculating different levels of protozoa with small difference, Showing the difference in the degree of infection, which provides a good animal model for immunological studies of leishmaniasis.