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目的 研究脑卒中时血清神经元特异性烯醇化酶 (NSE)的变化及与神经功能缺损的关系。方法 脑出血46例 ,脑梗死 6 9例 ,正常对照 2 1例。患者分别在起病 3d内及 2周时采集血标本。血清NSE测定采用酶联免疫分析方法 ,神经功能缺损评定按斯堪的纳维亚卒中量表 (SSS)标准进行。结果 脑梗死、脑出血组 3d内及起病 2周时血清NSE明显高于正常对照组 (均为P <0 .0 0 1) ,并与SSS呈明显正相关 (P <0 .0 0 1)。结论 脑卒中早期血清NSE明显升高 ,血清NSE与SSS之间有明显相关性。
Objective To investigate the changes of serum neuron-specific enolase (NSE) and its relationship with neurological deficits in stroke. Methods 46 cases of cerebral hemorrhage, 69 cases of cerebral infarction, 21 cases of normal control. Patients were collected within 3 days and 2 weeks of onset of blood samples. Serum NSE was measured by enzyme-linked immunosorbent assay and neurological deficit assessment was based on the Scandinavian Stroke Scale (SSS). Results The serum levels of NSE in cerebral infarction and intracerebral hemorrhage group were significantly higher than those in normal control group (both P <0. 001) within 3 days and 2 weeks after onset, and were positively correlated with SSS (P <0. ). Conclusion The serum level of NSE in the early stage of stroke is obviously increased, and there is a significant correlation between serum NSE and SSS.