本文以多甘醇为原料,经氧化、取代反应制备了多甘酰氯,再与仲胺反应,合成了7个开链酰胺型冠醚化合物和1个酰胺型大环化合物,除冠醚(Ⅰ)外,其余均未见文献报道。它们的结构经红外、核磁、质谱和元素分析数据确认,并用四圆单晶X射线衍射仪测定了冠醚(Ⅱ)单晶的晶体结构,进一步从理论上说明了它是优良的钙离子选择电极的中性载体。 In this paper, polyglycolyl chloride was prepared by the oxidation and substitution reaction of polyglycol as raw material, and then reacted with secondary amine to synthesize seven open-chain amide type crown ether compounds and one amide type macrocyclic compound. ), The rest have not been reported in the literature. Their structures were confirmed by IR, NMR, MS and elemental analysis. The crystal structure of the crown ether (Ⅱ) single crystal was measured by a tetragonal single crystal X-ray diffractometer. It is further theoretically proved that it is an excellent calcium ion selective Electrode neutral carrier.