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本文综述了重症疟疾和影响治疗效应的各种因素,概括常规方法检测抗疟药疗效的局限性,并讨论在不同的临床情况下,抗疟药毒性对治疗的重要性。一、影响治疗效应的疟原虫因素抗疟治疗的速度和效果取决于药物的选择、疟原虫的数量、期别和对药物的敏感性,以及宿主防卫机制的效能等诸因素。抗疟药疗效评价通常依据血内原虫的消失速度和再现率。原虫清除时间(PCT)常用作测定抗疟药疗效的重要依据。少于10~2/μl的原虫血症很难被常规的厚血膜检出。治疗后原虫可维持数日
This article reviews various aspects of severe malaria and the effects of treatment, summarizes the limitations of routine methods of detecting anti-malarial efficacy and discusses the importance of antimalarial toxicity for treatment in different clinical settings. First, the impact of the treatment effect of Plasmodium Antimalarial treatment of the speed and effect depends on the choice of drug, the number of Plasmodium, the stage and the sensitivity of the drug, and the host defense mechanism and other factors. Antimalarial efficacy evaluation is usually based on the disappearance of protozoan blood and the reproduction rate. Protozoal clearance time (PCT) is often used as an important basis for determining the efficacy of antimalarial drugs. Protozoosia of less than 10-2 / μl is hard to detect by conventional thick film. Protozoa can be maintained for several days after treatment