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目的:探讨多不饱和脂肪酸(PUFA)不同比值对结直肠癌病人术后营养状况、炎症反应和预后的影响。方法:将接受结直肠癌手术的40例病人随机分瑞能组(ω-6∶ω-3=2.5∶1)和能全力组(ω-6∶ω-3=5∶1),每组20例。病人均于术后第2～7天给予肠内营养支持,同时测定营养指标、炎症和免疫指标,记录并发症的发生率、肠功能恢复时间以及术后住院天数。结果:两组病人术后均出现体重、血清蛋白和免疫球蛋白下降,炎性因子升高。经治疗后,血清蛋白和免疫球蛋白均升高,瑞能组病人明显高于能全力组(P<0.05)。炎症指标下降,瑞能组明显低于能全力组(P<0.05)。瑞能组病人的肠功能恢复时间略早于能全力组,术后住院时间和并发症亦均少于能全力组(P<0.05)。结论:瑞能肠内营养治疗,能明显减轻结直肠癌病人术后的炎症反应,提高蛋白质合成速度、改善营养状况,促进肠功能恢复,提高机体免疫功能,减少术后并发症,缩短住院时间。
Objective: To investigate the effect of different PUFA ratio on nutritional status, inflammatory response and prognosis in patients with colorectal cancer. METHODS: Forty patients undergoing colorectal cancer surgery were randomized to receive either a canneon (ω-6: ω-3 = 2.5: 1) or a maximal group 20 cases. The patients were given enteral nutrition support on the 2nd to 7th day after surgery. At the same time, the nutritional indexes, inflammation and immune indexes were measured. The incidence of complications, the recovery time of intestinal function and hospital stay were recorded. Results: After operation, body weight, serum protein and immunoglobulin decreased, and inflammatory factors increased in both groups. After treatment, serum protein and immunoglobulin were increased, the patients in the Reneng group were significantly higher than those in the full group (P <0.05). Inflammation index decreased, Rui can group was significantly lower than the full group (P <0.05). The patients in the Rene group experienced a slightly earlier recovery of intestinal function than the full group, and the postoperative hospital stay and complications were less than those in the full group (P <0.05). Conclusion: Reneng Enteral Nutrition can significantly reduce postoperative inflammatory reaction, improve protein synthesis rate, improve nutritional status, promote intestinal function recovery, improve immune function, reduce postoperative complications and shorten hospital stay .