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目的系统评价牙周基础治疗对2型糖尿病相关性牙周炎患者血糖控制的影响,探讨牙周基础治疗在糖尿病治疗中的具体作用。方法计算机检索Cochrane图书馆对照试验注册中心、Medline、EMbase、SIGLE、GreyNet、NTIS、中国生物医学文献数据库、中文科技期刊全文数据库、中国期刊全文数据库和万方数据库,查找有关牙周基础治疗对糖尿病血糖控制影响的研究。检索时限均为1991—2011年4月31日。均由2名评价者独立选择试验、提取资料和评估方法学质量,然后采用RevMan 5.1软件对资料进行Meta分析。纳入7个研究,共计471例受试患者。结果牙周基础治疗能明显降低2型糖尿病相关性牙周炎患者糖化血红蛋白的水平,组间差异有统计学意义(95%CI:-0.94～-0.22,P=0.001)。治疗组牙周袋探诊深度低于对照组,组间差异也有统计学意义(95%CI:-2.26～-0.69,P=0.000 2)。结论牙周基础治疗有利于2型糖尿病相关性牙周炎患者总体血糖水平的控制。
Objective To systematically evaluate the effect of periodontal therapy on blood glucose control in type 2 diabetic patients with periodontitis and to explore the role of periodontal therapy in the treatment of diabetes mellitus. Methods The Cochrane Central Register of Controlled Trials, Medline, EMbase, SIGLE, GreyNet, NTIS, Chinese Biomedical Literature Database, Chinese Science and Technology Journals Full-text Database, Chinese Journal Full-text Database and Wanfang Database were searched by computer. Study on the Influence of Blood Glucose Control. The search time is from 1991 to April 31, 2011. Two evaluators independently selected trials, extracted data and assessed methodological quality, and then used RevMan 5.1 software to perform meta-analysis on the data. A total of 471 patients were included in the seven studies. Results The basic periodontal treatment could significantly reduce the level of HbA1c in type 2 diabetic patients with periodontitis (95% CI: -0.94-0.22, P = 0.001). The probing depth of the periodontal pocket in the treatment group was lower than that in the control group, and the difference between the two groups was also statistically significant (95% CI: -2.26-0.69, P = 0.0002). Conclusion Periodontal treatment is beneficial to the control of total blood glucose level in type 2 diabetic patients with periodontitis.