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目的 :通过观察胃癌术后病人白介素 - 2 (IL- 2 )治疗过程中外周血淋巴细胞表型、血清白介素 - 2受体(SIL- 2 R)和血清白介素 - 12 (IL- 12 )水平的变化 ,对胃癌术后患者的免疫机能的影响进行评价。方法 :胃癌术后患者 6 4例随机分成两组 :一组给予 IL- 2 ,另一组为对照组。用药前、后分别行 IL- 12和 SIL- 2 R测定以及用流式细胞仪测定淋巴细胞的表型。结果 :用药后血清 IL- 12及 CD4 +、CD8+、CD5 6 +比用药前明显升高 (P<0 .0 5 )。而 SIL- 2 R明显下降(P<0 .0 5 )。结论 :应用 IL - 2治疗胃癌术后患者 ,其细胞免疫机能明显改善。
OBJECTIVE: To investigate the changes of peripheral blood lymphocyte phenotypes, levels of serum interleukin 2 receptor (SIL-2R) and serum interleukin 12 (IL-12) during the treatment of patients with gastric cancer with interleukin-2 Changes, the effect of postoperative patients with gastric cancer immune function were evaluated. Methods: Sixty-four patients with postoperative gastric cancer were randomly divided into two groups: one was given IL-2 and the other was control group. Before and after treatment, IL-12 and SIL-2 R were measured and the phenotypes of lymphocytes were determined by flow cytometry. Results: Serum levels of IL-12, CD4 +, CD8 + and CD5 + were significantly higher than those before treatment (P <0.05). However, SIL-2 R decreased significantly (P <0.05). Conclusion: The application of IL - 2 in the treatment of postoperative patients with gastric cancer, the cellular immune function was significantly improved.