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目的探讨胱抑素C在急性胰腺炎继发急性肾损伤病情及预后评估中的价值。方法随机选择急性胰腺炎继发急性肾损伤30例(PAR组)、单纯急性胰腺炎患者30例(APS组)和健康者30例(CON组)。比较3组胱抑素C、血清肌酐(Scr)、血尿素氮(BUN)和急性生理学及慢性健康状况评价(APACHEⅡ)评分及病死率,并分析胱抑素C与Scr、BUN和APACHEⅡ评分的相关性。结果 PAR组患者胱抑素C、Scr、BUN、APACHEⅡ评分和病死率均高于APS组和CON组,差异均有统计学意义(P均<0.05);APS组患者APACHEⅡ评分高于CON组,差异有统计学意义(P<0.05),但2组胱抑素C、Scr、BUN和病死率的差异均无统计学意义(P均>0.05)。PAR组患者胱抑素C与Scr、BUN及APACHEⅡ评分均呈正相关(rs=0.318、0.255、0.395,P均<0.05);APS组患者胱抑素C与Scr、BUN及APACHEⅡ评分均无相关关系(P均>0.05)。结论胱抑素C在急性胰腺炎继发急性肾损伤时显著升高,可作为其病情及预后评估的标志物。
Objective To investigate the value of cystatin C in evaluating the prognosis and prognosis of acute renal injury secondary to acute pancreatitis. Methods Thirty patients with acute renal injury secondary to acute pancreatitis (PAR group), 30 patients with acute pancreatitis (APS group) and 30 healthy individuals (CON group) were randomly selected. The levels of cystatin C, serum creatinine (Scr), blood urea nitrogen (BUN) and acute physiology and chronic health evaluation (APACHEⅡ) and mortality were compared between the three groups. The levels of cystatin C, Scr, BUN and APACHEⅡ Correlation. Results The scores of Cystatin C, Scr, BUN, APACHEⅡ and mortality in PAR group were higher than those in APS group and CON group (all P <0.05). The APACHEⅡ score in APS group was higher than that in CON group, The difference was statistically significant (P <0.05), but there was no significant difference in the two groups of cystatin C, Scr, BUN and mortality (P all> 0.05). Cystatin C in PAR group was positively correlated with Scr, BUN and APACHEⅡscore (rs = 0.318,0.255,0.395, P <0.05). There was no correlation between cystatin C and Scr, BUN and APACHEⅡscore in APS group (P> 0.05). Conclusions Cystatin C is significantly increased in patients with acute renal injury secondary to acute pancreatitis and can be used as a marker for the assessment of its condition and prognosis.