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目的 探讨足月儿在不同分娩方式时脐血白细胞介素 6 (IL 6 )和肿瘤坏死因子 α(TNF α)水平的变化及临床意义。方法 采用ELISA法检测 6 8例阴道分娩、择期剖宫产和急诊剖宫产足月儿脐血和产妇血浆IL 6和TNF α水平。结果 急诊剖宫产组脐血IL 6和TNF α显著高于阴道分娩组和择期剖宫产组 ,阴道分娩组与择期剖宫产组脐血IL 6和TNF α无显著差异 ;阴道分娩、择期剖宫产和急诊剖宫产三组母血IL 6都高于相应脐血 ,且与脐血IL 6呈正相关。结论 分娩应激脐血IL 6水平可能受母体影响。胎儿宫内窘迫可使脐血IL 6和TNF α上升 ,但幅度较小 ;脐血细胞因子的变化与分娩方式关系不大。
Objective To investigate the changes and clinical significance of interleukin 6 (IL 6) and tumor necrosis factor α (TNF α) in full-term infants under different modes of delivery. Methods The levels of IL-6 and TNF-α in 68 cases of vaginal delivery, elective cesarean section and full-term cesarean section cord blood and maternal plasma concentrations were detected by ELISA. Results The cord blood IL 6 and TNFα in emergency cesarean section group were significantly higher than that in vaginal delivery group and elective cesarean section group. There was no significant difference in umbilical cord blood IL 6 and TNFα between vaginal delivery group and elective cesarean section group. Vaginal delivery and elective period Cesarean section and emergency cesarean section three groups of maternal blood IL 6 are higher than the corresponding cord blood, and cord blood IL 6 was positively correlated. Conclusion The level of IL-6 in cord blood during labor may be influenced by the mother. Fetal distress can make cord blood IL 6 and TNF α increased, but less; changes in cord blood cytokines have little to do with the mode of delivery.