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目的:比较观察胎膜早破结局患者与正常妊娠结局患者妊娠晚期阴道微生态环境状况。方法:选择有完整产检史的妊娠期患者50例,分为胎膜早破结局组20例和正常妊娠结局组30例。对所有患者妊娠36周时的产检数据进行分析,比较两组阴道pH、乳酸杆菌优势率、唾液酸酶阳性率及分泌物免疫因子水平。结果:胎膜早破结局组阴道pH为(4.10±0.25),显著高于正常妊娠结局组的(3.82±0.25)(P<0.05);乳酸杆菌优势率为35.0%,非常显著低于正常妊娠结局组的86.7%(P<0.01);阴道唾液酸酶阳性率为45.0%,非常显著高于正常妊娠结局组的13.3%(P<0.01)。胎膜早破结局组分泌型免疫球蛋白A(SIgA)、免疫球蛋白E(IgE)及人防御素5(HD5)水平均显著高于正常妊娠结局组(P<0.05)。结论:胎膜早破患者阴道pH、阴道唾液酸酶阳性率及局部免疫因子水平均较正常妊娠患者显著升高,乳酸杆菌优势率较正常妊娠患者显著降低,因此,胎膜早破可能与妊娠晚期阴道微生态环境失调具有一定相关性。
Objective: To comparatively observe the status of vaginal microflora in late pregnancy in patients with premature rupture of membranes and patients with normal pregnancy outcome. Methods: 50 pregnant women with a complete history of pregnancy were selected and divided into 20 cases of premature rupture of membranes group and 30 cases of normal pregnancy. All patients at 36 weeks of pregnancy production test data were analyzed to compare the two groups of vaginal pH, lactobacillus odds ratio, sialidase positive rate and secretion of immune factors. Results: The vaginal pH of premature rupture of membranes group was (4.10 ± 0.25), significantly higher than that of normal pregnancy group (3.82 ± 0.25) (P <0.05). The prevalence of lactobacillus was 35.0%, which was significantly lower than that of normal pregnancy (P <0.01). The positive rate of vaginal sialidase was 45.0%, which was significantly higher than that of the normal pregnancy group (13.3%, P <0.01). The levels of SIgA, IgE and HD5 in premature rupture of membranes were significantly higher than those in normal pregnancy (P <0.05). CONCLUSIONS: The vaginal pH, vaginal sialidase positive rate and local immune factor level in patients with premature rupture of membranes are significantly higher than those in normal pregnant women, and the prevalence of lactobacilli is significantly lower than that in normal pregnant women. Therefore, premature rupture of membranes may be related to pregnancy Late vaginal micro-ecological disorders have some relevance.