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［目的］研究转化生长因子-β1Ⅱ型变体（TGF-β1RⅡ）在肝细胞癌蛋白水平的表达及意义。［方法）用免疫组化染色（LSAB法）分别检测30例肝癌组织和癌旁肝组织中TGF-β1RⅡ的表达。［结果]TGF-β1RⅡ染色，在肝癌组织以阴性（14例）和弱阳性（10例）为主；在癌分组织以弱阳性（8例）和阳性（11例）为主。经统计学处理，两组差别有显著性意义（P＜0.05）。（结论]TGF-β1RⅡ在肝癌组织表达降低，导致肝癌细胞及性生长调控障碍，可能是其癌变和生长失控的重要原因之一。
[Objective] To study the expression and significance of transforming growth factor-β1 type II variant (TGF-β1RII) in hepatocellular carcinoma protein. [Methods] The expression of TGF-β1RII in 30 cases of hepatocellular carcinoma and adjacent liver tissues was detected by immunohistochemical staining (LSAB). [Results] The staining of TGF-β1 RII was mainly negative in hepatocellular carcinoma (14 cases) and weakly positive (10 cases). In the cancer tissue, it was mainly weak positive (8 cases) and positive (11 cases). After statistical analysis, there was a significant difference between the two groups (P<0.05). (Conclusion) The decreased expression of TGF-β1RII in hepatocellular carcinoma may lead to impaired regulation of hepatocellular carcinoma cells and sexual growth, which may be one of the important causes of cancerous growth and uncontrolled growth.