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目的通过川崎病(KD)患儿血浆D-二聚体的变化研究川崎病血管损伤的机制,并探讨D-二聚体改变与KD合并冠状动脉病变之间的关系。方法应用乳胶凝集法(Latex法)检测52例KD患儿、45例健康对照组儿童的血浆D-二聚体。结果KD患儿组血浆D-二聚体高于健康对照组,差异有统计学意义(P<0.05)。合并冠状动脉病变(CAD)组血浆D-二聚体明显增高,D-二聚体高于无冠状动脉病变(NCAD)组,与NCAL组相比差异有统计学意义(P<0.05)。结论D-二聚体在KD患儿血管损伤发生发展中有着密切关系。D-二聚体的升高反映了川崎病存在明显的高凝状态、纤溶异常和血栓形成倾向,对冠状动脉病变的并发症具有很大预测价值。
OBJECTIVE: To investigate the mechanism of vascular injury caused by Kawasaki disease in children with Kawasaki disease (KD) and to investigate the relationship between D-dimer changes and coronary lesions in patients with KD. Methods Latex method was used to detect plasma D-dimer in 52 children with KD and 45 healthy controls. Results The plasma D-dimer in children with KD was significantly higher than that in healthy controls (P <0.05). D-dimer was significantly higher in CAD group than in NCAD group, and the difference was statistically significant (P <0.05). Conclusion D-dimer is closely related to the occurrence and development of vascular injury in children with KD. D-dimer reflects the existence of Kawasaki disease obvious hypercoagulable state, fibrinolytic abnormalities and thrombophilia, the complications of coronary artery disease has great predictive value.