温度影响非去极化肌松药的药效.降温时,有人报道肌松药药效减低;但也有人认为随温度降低而药效增强。作者用大鼠的膈神经膈肌备制标本,在灌注液中维持稳定的肌松药浓度,即在药动学不变的情况下,研究右旋简箭毒,潘侃朗宁、美多冠林(碘甲筒箭毒)和三碘季铵酚在25°、31°和37℃三种不同温度时的药效学。 Temperature affects the efficacy of non-depolarizing muscle relaxants.When cooling, it was reported to reduce the efficacy of muscle relaxants; but some people think that with the temperature decreases and the efficacy increased. The author uses rat phrenic nerve diaphragm preparation of specimens in the perfusate to maintain a stable concentration of muscle relaxants, that is, in the same pharmacokinetic study dextrose dextrose, Pan Kan Lang Ning, the United States more crown forest ( Iodoformisteromycin) and triiodide quaternary ammonium phenol at 25 °, 31 ° and 37 ° C at three different temperatures Pharmacodynamics.