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目的:探讨食管癌患者的血清白细胞介素和急性时相反应蛋白的含量变化及其临床意义。方法:选择食管癌患者46例作为观察组,其中早期(Ⅰ～Ⅱ)食管癌患者25例、晚期(Ⅲ～Ⅳ)食管癌患者21例,测定患者的血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)和急性时相反应蛋白中的C反应蛋白(CRP)、转铁蛋白(TRF)、前清蛋白(PAB),以健康体检合格人群42例作为对照组,分析食管癌患者的血清白细胞介素和急性时相反应蛋白的含量变化特点。结果:与对照组比较,观察组血清IL-6、IL-8水平均明显增高(P<0.05),TNM分期(Ⅲ+Ⅳ)食管癌患者升高更为明显(P<0.05);与对照组比较,观察组血清CRP水平明显增高(P<0.05),TRF、PAB水平明显降低(P<0.05),TNM分期(Ⅲ+Ⅳ)食管癌患者变化更为明显(P<0.05)。结论:食管癌患者的血清白细胞介素和急性时相反应蛋白含量变化能够反映病情变化,有助于食管癌的临床诊断。
Objective: To investigate the changes of serum interleukin and acute phase reaction protein in patients with esophageal cancer and its clinical significance. Methods: Forty-six patients with esophageal cancer were selected as the observation group. Among them, 25 cases of early stage (Ⅰ ~ Ⅱ) esophageal cancer and 21 cases of advanced stage Ⅲ ~ Ⅳ esophageal cancer were measured. Serum interleukin-6 ), Interleukin-8 (IL-8) and acute phase reaction protein C reactive protein (CRP), transferrin (TRF), prealbumin (PAB), 42 healthy people eligible for examination as a control Group, analysis of esophageal cancer patients with serum interleukin and acute phase reaction protein content changes. Results: Compared with the control group, the levels of serum IL-6 and IL-8 in the observation group were significantly increased (P <0.05), while those in the TNM stage (Ⅲ + Ⅳ) esophageal cancer were significantly increased (P <0.05) The levels of CRP, TRF and PAB in observation group were significantly higher than those in control group (P <0.05). The changes of esophageal cancer in TNM stage (Ⅲ + Ⅳ) were more obvious (P <0.05). Conclusion: The changes of serum interleukin and acute phase reaction protein in patients with esophageal cancer can reflect the changes of the disease and contribute to the clinical diagnosis of esophageal cancer.