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采用酰氯法合成了一种山梨酸衍生物——N-异丁基山梨酰胺.降血脂药效实验发现,N-异丁基山梨酰胺在预防性高血脂症动物实验中,表现出降低血清TC值(P=0.085 8)和显著降低血清LDL-C(P=0.011 6)的功效,具有良好的降血脂作用.
A kind of sorbic acid derivative, N-isobutyl sorbieamide, was synthesized by acid chloride method.The hypolipidemic efficacy experiment showed that N-isobutyl sorbamide showed lower serum TC in animal experiments of preventive hyperlipidemia (P = 0.085 8) and significantly reduce the serum LDL-C (P = 0.011 6), with good hypolipidemic effect.