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目的用meta分析方法研究ABO血型在糖尿病患者和健康人群中的分布情况,以评价ABO血型系统与糖尿病发生风险的关系。方法通过检索PubMed、中国生物医学文献数据库、维普中文科技期刊数据库、中国知网期刊数据库和万方数据库等,收集有关糖尿病与ABO血型系统之间关系的原始文献,按照纳入与排除标准筛选出符合要求的文献并提取出相关的数据,使用NOS量表对纳入文献进行质量评价,采用Review Manager 5.1和Stata 12.0软件进行meta分析。结果 B血型和AB血型在糖尿病患者和对照人群中的分布差异有统计学意义,表现为B血型在糖尿病患者中所占比例高于对照人群(OR=1.13,95%CI:1.05~1.21,P=0.000 7),AB血型则在对照人群中更为常见(OR=0.86,95%CI:0.77~0.97,P=0.01);但亚组分析时发现B血型和AB血型的分布差异仅在国外人群中有统计学意义(P<0.05)。而A血型(OR=0.90,95%CI:0.76~1.07,P=0.24)和O血型(OR=1.00,95%CI:0.89~1.13,P=0.96)在两组中的分布差异无统计学意义。结论糖尿病的发生可能与ABO血型有关。国外人群中B血型的糖尿病发病风险高于其他血型,AB血型可能是糖尿病发生的保护因子,而A血型和O血型在国内外人群中与糖尿病的发生均无关。
Objective To study the distribution of ABO blood group in patients with diabetes mellitus and healthy people by meta-analysis to evaluate the relationship between ABO blood group system and the risk of diabetes. Methods The original literatures about the relationship between diabetes and ABO blood group system were collected by searching PubMed, Chinese Biomedical Literature Database, VIP Chinese Science and Technology Periodical Database, Chinese Knowledge Network Periodical Database and Wanfang Database. According to inclusion and exclusion criteria, The required literature was extracted and the relevant data extracted. The quality of the included literature was evaluated using the NOS scale. Meta-analysis was performed using Review Manager 5.1 and Stata 12.0 software. Results The distribution of B blood group and AB blood group in diabetic patients and control patients was statistically significant, showing that the proportion of blood group B in diabetes was higher than that in control group (OR = 1.13, 95% CI: 1.05-1.21, P = 0.000 7). The AB blood group was more common in control subjects (OR = 0.86, 95% CI: 0.77-0.97, P = 0.01). However, in the subgroup analysis, the distribution of B blood type and AB blood type was only found in foreign countries The population was statistically significant (P <0.05). There was no significant difference in the distribution of blood type A (OR = 0.90,95% CI: 0.76-1.07, P = 0.24) and O blood type (OR = 1.00,95% CI: 0.89-1.13, P = 0.96) significance. Conclusion The incidence of diabetes may be related to ABO blood group. In the foreign population, the risk of type B diabetes is higher than that of other blood types. The blood type AB may be the protective factor of diabetes, while the blood type A and type O are not related to the occurrence of diabetes at home and abroad.