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自1828年以来,已报道了二百余例急性吞酸事件,但无对照研究以确定酸浓度增高对食管和胃粘膜的影响。本文的目的在于复习有关人类中吞酸的文献经验,以及确定不同酸浓度对空腹和喂饲狗食管、胃和十二指肠粘膜的影响。实验模型方法取6条狗,用硫苯妥钠麻醉,于胃底和胃窦部分别置测温探子。将硫酸(10 N、20 N、36 N)灌入近端食管。吞酸后经常测胃粘膜温度凡20分钟,并经内窥镜记录最终的粘膜病灶程度(正常粘膜为0,充血为1+,粘膜脱落伴焦痂为2+,全层坏死为3+)。吞酸后30分钟,杀死全部动物,从肉眼和组织学上将远端食管、胃底、胃窦和十二指肠的灼伤范围进行分级(正常为0,急性炎症为1+,浅层凝固性坏死为2+,全层凝固性坏死为3+)。结果硫酸使组织发生凝固性坏死和分解。不象
Since 1828, more than 200 acute cases of acidosis have been reported, but no controlled studies have been performed to determine the effect of increased acidity on esophageal and gastric mucosa. The purpose of this article is to review the literature on human acid transphase and to determine the effect of different acid concentrations on the fasting and feeding dogs’ esophagus, stomach and duodenal mucosa. Experimental model method Take 6 dogs, anesthesia with sodium thiophene, in the stomach and gastric antrum respectively set temperature probe. Sulfuric acid (10 N, 20 N, 36 N) was infused into the proximal esophagus. The temperature of the gastric mucosa is usually measured for 20 minutes after the titration, and the final mucosal lesion is recorded by endoscopy (normal mucosa is 0, hyperemia is 1+, mucosal exfoliation with eschar is 2+ and full-thickness necrosis is 3+) . Thirty minutes after the acid was swallowed, all animals were sacrificed and the extent of burns in the distal esophagus, gastric fundus, antrum and duodenum were graded visually and histologically (normal 0, acute inflammation 1+, superficial Coagulation necrosis is 2+, full-thickness coagulation necrosis is 3+). Sulfuric acid results in coagulation necrosis and decomposition of the tissue. Not like