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Gangul等曾发现,M-激动剂oxotremorine可使大鼠膈神经-膈制备(phrenic nerve-diaphragm preparation)的ACh释放增加,而M-阻断剂阿托品则使之减少。然而,Abbs等最近在类似的实验中却得到截然不同的结果。他们将成年Wistar大鼠的膈神经-膈制备与[~3H-甲基]-胆碱共同孵育后测定了阿托品和oxotremorine对该制备释放ACh的影响。发现阿托品(10~(-6)-10~(-5)M)不影响静息情况下ACh的释放,但阿托品(10~(-5)M)可增强电刺激引起的ACh释放;oxotremorine(10~(-5)M)对静息时及电刺激引起的ACh释放均无影响;阿托品(10~(-5)M)与oxotremorine(10~(-5)M)
Gangul et al. Have found that the M-agonist oxotremorine increases the ACh release from the phrenic nerve-diaphragm preparation in rats, whereas the M-blocker atropine decreases it. However, Abbs et al. Recently achieved very different results in similar experiments. They measured the effects of atropine and oxotremorine on the release of ACh after incubation of phrenic nerve-diaphragm preparation with [~ 3H-methyl] -choline in adult Wistar rats. It was found that atropine (10 -6 -6 -10 -5 M) did not affect ACh release at rest, but atropine (10 -5 M) increased ACh release induced by electrical stimulation. Oxotremorine 10 ~ (-5) M) had no effect on ACh release caused by resting and electrical stimulation; atropine (10 -5 M) and oxotremorine (10 -5 M)