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目的探讨2型糖尿病(T2DM)患者血清血管性血友病因子(vWF)与颈动脉粥样硬化的相关性。方法采用ELISA法检测T2DM合并颈动脉斑块患者(A组,60例)、T2DM未合并颈动脉斑块患者(B组,60例)及正常对照人群(C组,56例)血清vWF水平,同时检测血脂、空腹胰岛素(FIns)、超敏C反应蛋白(hsCRP)、FBG、HbA1c的表达。结果 A、B组血清vWF水平均高于C组(P<0.05),A组血清vWF水平亦高于B组(P<0.05)。T2DM患者血清vWF水平与TG、SBP、hsCRP、FBG和HbA1c呈正相关(r=0.200、0.210、0.270、0.504和0.440,P<0.05),与HDL-C呈负相关(r=―0.280,P<0.05)。vWF、HbA1c和HDL-C是T2DM患者发生颈动脉粥样硬化的独立影响因素。结论 vWF可能参与T2DM患者颈动脉粥样硬化的发生和发展。
Objective To investigate the relationship between serum von Willebrand factor (vWF) and carotid atherosclerosis in type 2 diabetes mellitus (T2DM). Methods Serum levels of vWF were measured by ELISA in patients with T2DM complicated with carotid plaque (group A, 60 cases), T2DM without carotid plaque (group B, 60 cases) and normal control group (group C, 56 cases) At the same time, the levels of blood lipids, fasting insulin (FIns), hsCRP, FBG and HbA1c were detected. Results The serum levels of vWF in group A and group B were significantly higher than those in group C (P <0.05). The serum levels of vWF in group A were also significantly higher than those in group B (P <0.05). Serum levels of vWF in T2DM patients were positively correlated with TG, SBP, hsCRP, FBG and HbA1c (r = 0.200,0.210,0.270,0.504 and 0.440, P <0.05), but negatively correlated with HDL- 0.05). vWF, HbA1c and HDL-C are independent risk factors for carotid atherosclerosis in T2DM patients. Conclusion vWF may be involved in the occurrence and development of carotid atherosclerosis in T2DM patients.