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目的探讨血清胱抑素C对小儿急性肾功能衰竭的诊断价值。方法收集32例有急性肾功能衰竭的患儿(肾功能衰竭组)和同期30例体检正常的儿童(正常对照组)血清标本,用酶法测定血清肌酐(Scr)、尿素氮(BUN),用乳胶颗粒增强免疫比浊法测定血清胱抑素C(Cystatin C),比较两组患儿Scr、BUN及Cystatin C的差异。结果肾功能衰竭组患儿血清Cystatin C水平均较正常对照组明显升高,肾功能衰竭组与对照组比较差异有统计学意义(P<0.01)。Cystatin C与BUN、Scr均呈正相关,与肌酐清除率(Ccr)呈负相关,且与Ccr相关性高于Scr与Ccr的相关性,Cystatin C与肾小球滤过功能密切相关。结论血清胱抑素C水平是评估小儿急性肾功能衰竭较敏感的指标。
Objective To investigate the diagnostic value of serum cystatin C in children with acute renal failure. Methods Serum samples of 32 children with acute renal failure (renal failure group) and 30 normal children (normal control group) were collected during the same period. Serum creatinine (Scr), blood urea nitrogen (BUN) Serum cystatin C levels were measured by latex particle-enhanced immunoturbidimetry and the differences in Scr, BUN and Cystatin C between the two groups were compared. Results The serum levels of Cystatin C in children with renal failure group were significantly higher than those in normal control group. There was significant difference between the renal failure group and the control group (P <0.01). Cystatin C was positively correlated with BUN and Scr, but negatively correlated with Ccr. The correlation between Cystatin C and Ccr was higher than that between Scr and Ccr. Cystatin C was closely related to glomerular filtration function. Conclusions Serum cystatin C level is a more sensitive index for evaluating acute renal failure in children.