Dome A in Antarctica has been demonstrated to be the best site on earth for optical, infrared, and terahertz astronomical observations by more and more evidence, such as excellent free-atmosphere seeing,extremely low perceptible water vapor, low sky background, and continuous dark time, etc. In this paper,we present a complete picture of the development of astronomy at Dome A from the very beginning, review recent progress in time-domain astronomy, demonstrate exciting results of the site testing, and address the challenges in instrumentation. Currently proposed projects are briefly discussed.